Syfy og Trion Worlds har jobbet sammen med Defiance allerede siden før TV-serien gikk på lufta i 2013. Det er et prosjekt som også går over i spillutgaven ved at handlingen også påvirker onlinespillet fra Trion Worlds. Nå har TV-serien blitt kansellert, og Syfy har følgende kommentar:
"Defiance was a truly groundbreaking series, delivering an immersive, cross-platform experience that transcended the television screen in a way that viewers had never seen before. We are incredibly proud of the work of the extraordinary cast, writers, artists and designers — and especially showrunner Kevin Murphy — who together brought the rich world of 'Defiance' to life over its three season arc."
Men Trion Worlds har ingen planer om å følge etter. Dette forteller de til Polygon der sjef Scott Hartsman sier:
"We've had a great time working closely with the team of stellar writers, designers, producers, and actors on the Defiance TV show. Like many of you, we've all enjoyed the stories they told week in and week out. Let's treat this as a fond farewell, in celebration of a successful three year run of a show that broke a lot of new ground and brought an incredible quality experience to its viewers.
As for the game and its future, Defiance is Trion's IP and the game will continue exactly as before. The show has always been a fantastic and interesting partner, but the two were always meant to be able to stand on their own, which is why the show was primarily set in St. Louis and the game in the SF Bay Area."